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  • 产品名称:3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 (PAPSS1) Antibody

  • 产品型号:abx031631
  • 产品厂商:其它品牌
  • 产品价格:170
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简单介绍:
3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 (PAPSS1) Antibody
详情介绍:
Sulfotransferase (SULT) enzymes catalyze the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters. 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase (PAPSS) catalyzes the biosynthesis of PAPS which serves as the universal sulfonate donor compound for all sulfotransferase reactions. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (603005). Bifunctional PAPSS1 is comprised of an N-terminal APS kinase domain, and a C-terminal ATP sulfurylase domain. Full-length protein has significantly less APS kinase activity than the N-terminal fragment, suggesting that the C-terminal domain exerts a regulatory role on the N-terminal APS kinase activity. In humans there are two major isoforms: PAPSS1 and PAPSS2. In brain and skin PAPSS1 is the major isoform, whereas in liver, cartilage and adrenal glands PAPSS2 isoform expression dominates. The predicted 623-amino acid protein is 98% identical to mouse PAPS synthase. The N-terminal 268-amino acid region of human PAPS synthase resembles APS kinases from other organisms and contains 3 conserved nucleotide-binding motifs.

Target PAPSS1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Tested Applications WB
Recommended dilutions Optimal dilutions/concentrations should be determined by the end user.
Immunogen Human PAPSS1.
Purification Purified Rabbit Polyclonal Antibody.
Isotype IgG
Conjugation Unconjugated
Specificity This PAPSS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 592-624 amino acids from the C-terminal region of human PAPSS1.
Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Swiss Prot O43252
Gene Symbol PAPSS1
NCBI Accession NP_005434.4
Buffer PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
UNSPSC Code 12352203
Availability Shipped within 5-10 working days.
Note This product is for research use only.
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